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Veröffentlichungen List of Publications


Publikationen Publications


Abstracts/Posters Abstracts/Posters



Wirkstofffindung und Target Validierung – Allgemeine Konzepte Drug Discovery and Target Validation – General Concepts

Plenge RM. Disciplined approach to drug discovery and early development. Sci Transl Med. (2016) PMID: 27464747


Sweis RF. Target (In)Validation: A Critical, Sometimes Unheralded, Role of Modern Medicinal Chemistry. ACS Med Chem Lett. (2015) PMID: 26101559


Frigault MM, Barrett JC. Is target validation all we need? Curr Opin Pharmacol. (2014) PMID: 25261632


Gashaw I, Ellinghaus P, Sommer A, Asadullah K. What makes a good drug target? Drug Discov Today (2012) PMID: 22155646


Carney S. Target validation. Drug Discov Today (2012) PMID: 22155225


Bunnage ME. Getting pharmaceutical R&D back on target. Nat Chem Biol. (2011) PMID: 21587251


Hughes JP, Rees S, Kalindjian SB, Philpott KL. Principles of early drug discovery. Br J Pharmacol. (2011) PMID: PMC3058157


Chen XP, Du GH. Target validation: A door to drug discovery. Drug Discov Ther. (2007) PMID: 22504361


Plata-Salamán CR, Ilyin SE. Considerations for target validation and industrial approaches. Methods Mol Biol. (2007) PMID: 17172719


Smith C. Drug target validation: Hitting the target. Nature (2003) PMID: 12646927


Target Validierung - Bezogen auf klinische Indikationen Target Validation - related to clinical indications

Settleman J, Sawyers CL, Hunter T. Challenges in validating candidate therapeutic targets in cancer. Elife (2018) PMID: 29417929


Kaelin WG Jr. Common pitfalls in preclinical cancer target validation. Nat Rev Cancer (2017) PMID: 28524181


Blagg J, Workman P. Chemical biology approaches to target validation in cancer. Curr Opin Pharmacol. (2014) PMID: 25175311


Cortés-Cros M, Schmelzle T, Stucke VM, Hofmann F. The path to oncology drug target validation: an industry perspective. Methods Mol Biol. (2013) PMID: 23436402


Wirkstofffindung in Wissenschaft und Industrie Drug Discovery in Academia and Industry

Edwards A. Reproducibility: Team up with industry. Nature (2016) PMID: 26983524

Everett JR. Academic drug discovery: current status and prospects. Expert Opin Drug Discov. (2015) PMID: 26088126

Frearson J, Wyatt P. Drug Discovery in Academia- the third way? Expert Opin Drug Discov. (2010) PMID: 20922062

Frye SV. Drug discovery in academic institutions. Hematology Am Soc Hematol Educ Program (2013) PMID: 24319195

Jasny BR, Wigginton N, McNutt M, Bubela T, Buck S, Cook-Deegan R, Gardner T, Hanson B, Hustad C, Kiermer V, Lazer D, Lupia A, Manrai A, McConnell L, Noonan K, Phimister E, Simon B, Strandburg K, Summers Z, Watts D. Fostering reproducibility in industry-academia research. Science (2017) PMID: 28839064

Jones LH. An industry perspective on drug target validation. Expert Opin Drug Discov. (2016) PMID: 27111834

Loregian A, Palù G. How academic labs can approach the drug discovery process as a way to synergize with big pharma. Trends Microbiol. (2013) PMID: 23731493

Mullard A. Reliability of 'new drug target' claims called into question. Nat Rev Drug Discov. (2011) PMID: 21878966

Ohlmeyer M, Zhou MM. Integration of small-molecule discovery in academic biomedical research. Mt Sinai J Med. (2010) PMID: 20687180

Rosenblatt M. How academia and the pharmaceutical industry can work together: the president's lecture, annual meeting of the American Thoracic Society, San Francisco, California. Ann Am Thorac Soc. (2013) PMID: 23509330

Tralau-Stewart CJ, Wyatt CA, Kleyn DE, Ayad A. Drug discovery: new models for industry-academic partnerships. Drug Discov Today (2009) PMID: 18992364


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Abstract/Poster 2019 Abstract/Poster 2019

6. WCRI (World Conference on Research Integrity) 2019

Emmerich CH, Martinez-Gamboa L, Gerlach B, Bespalov A, Hofmann M, Bonin-Andresen M, Schendel P, Parnham M, Dirnagl U. GOT-IT - Guidelines On Target Validation for Innovative Therapeutics. (Abstract / Poster)